HLA-G 2019


JULY 8, 2019

PLENARY SESSION 1

 HLA-G

Chairpersons: Edgardo D. Carosella, Katsumi Maenaka

09:30 - 11:20

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E. D. Carosella : Opening address

France

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Silvia Gregori  : "HLA-G expressing DC-10 and tolerance"

Italy

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Diana Le Roux : "The expanding landscape of HLA-G isoforms"

France

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Claudia Rössig : "HLA-G in the tumor microenvironment of Ewing sarcomas - A barrier to effective CAR T cell targeting ?"

Germany    

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Anatolij Horuzsko : "The renaissance of HLA-G in transplantation"

USA

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Roberta Rizzo : "HLA-G and female infertility"

Italy

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COFFEE BREAK 11:20 - 11:40

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SYMPOSIUM

I

HLA-G IN CANCER

Chairpersons : Enrico Fainardi, Bela Papp

 

 

11:40 - 13:30

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"Impact of the immune-checkpoint HLA-G/ILT4 on the expression of VEGF in clear cell renal cell carcinoma"

Marcela García, Maria Belen Palma, Jérôme Verine, Santiago Miriuka, Ana M Inda, Ana L Errecalde, François Desgrandschamps, Edgardo D. Carosella, Diana Tronik-Le Roux

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"Roles of HLA-G in tumor immune evasion by MDSCs proliferation and the M1/M2macrophage differentiation"

Jun Gan, Hui-Hui Xu, Wei Hua Yan

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"Expression and clinical significance of plasma sHLA-G in exosome in patients with colorectal cancer"

Zhangsheng Zhao, Xia Zhang, Ruili Zhang, Wei Hua Yan, Ai-Fen Lin  

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"Detection of HLA-G expression in colorectal cancer"

Daniëlle Krijgsman, Marloes Swets, Ronald L.P. van Vlierberghe, Merve Eken, Cornelis F.M. Sier, Peter J. van den Elsen, Peter J.K. Kuppen

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"High Expression of HLA-G in Ovarian Carcinomatosis: The Role of Interleukin-1β"

Matti Ullah, Dallel Azazzen, Rachid Kaci, Nadia Benabbou, Eric Pujade Lauraine, Marc Pocard, Massoud Mirshahi

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"In vitro modification of cancer cells for the study of HLA class Ia and Ib molecules in relation to specific regulatory immune cell responses"

Nanna Jørgensen, Abid Sayed, Jesper T. Troelsen, Thomas Vauvert F. Hviid

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"Cytometry-based analysis of HLA-G functions according to ILT2 expression"

Alix Jacquier, Clement Dumont, Edgardo D. Carosella, Nathalie Rouas-Freiss, Joel LeMaoult

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"The microRNA miR-5096, a putative regulator of HLA-G gene, is differentially expressed in T- and B-acute lymphoblastic leukemia and is associated with distinct sHLA-G bone marrow levels"

Renata dos Santos Almeida, Eduardo Antônio Donadi, Norma Lucena-Silva

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"Targeting the coding sequence: microRNAs regulate classical and non-classical HLA molecules"

Michael Friedrich, Anja Mueller, Barbara Seliger

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"HLA-G 3′ untranslated region polymorphisms are associated with the progression of cervical lesion in human papillomavirus type 18 infection"

Hui-Hui Xu, Ai-Fen Lin, Wei-Hua Yan.

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"Influence of genotypes and haplotypes of the 14bp Ins/Del and + 3142C/G loci of the HLA-G gene on the expression of the molecule in patients with malignant gliomas"

Kênia C.S.F Magalhães, Karla R. Silva, Nathália A. Gomes, Gervásio T. Carvalho, Marcelo A. Buzellin,      Igor M. Maia, Lucas A. F. Albuquerque, Gerival Vieira-Junior, Renata T. Simões

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"HLA-G & Cadherin Profile Expression, and its Prognostic Value in Renal Cell Carcinoma"

Berta Sáez-Gutiérrez,  Cristina Plaza Alonso, María Tobeña Puyal, Joaquín Gimeno Pelegrin, Patricia    Sota Ochoa, Alejandro  López del Val, Manuel Gómez Barrera, Joaquín Navarro Gil, Victoria     Capapé Poves, Jose Manuel Sánchez Zalabardo

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LUNCH BREAK 13:30 – 14:30

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PLENARY SESSION

2

HLA-G IMMUNE  FUNCTION


Chairpersons : Joël LeMaoult, Vera Rebmann

14:30 – 15:50

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Nathalie Rouas-Freiss : "HLA-G: a major immune checkpoint molecule"

France

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Katsumi Maenaka : "Functional and structural roles of HLA-G as an Immune checkpoint molecule"

Japan

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Deborah Burshtyn : "LILRB1 receptor variation impacts interaction with HLA-G"

Canada

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Ofer Mandelboim : "Human NK cells remember pregnancy : role of HLA-G"

Israel

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COFFEE BREAK 15:50 – 16:15

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SYMPOSIUM

II

HLA-G AND DISEASE

Chairpersons: Eduardo A. Donadi, Jean-Philippe Deslys

16:15 - 18:00

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"Exploring tolerogenic DC-10 and HLA-G as new related biomarkers of Type 1 Diabetes"

Giada Amodio, Alessandra Mandelli, Angela Stabilini, Paola Rancoita, Manuela Battaglia, Silvia Gregori sssssssssssssssssssssssssssss

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"Epistatic interactions between HLA-G and its main receptors LILRB1 and LILRB2 in the Brazilian population"

Oliveira M.L.G; Veiga-Castelli L.C.; Souza A.S., Cardili R.N., Courtin D., Donadi E.A.; Castelli E.C.,  Sabbagh A., Mendes-Junior C.T.

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"Plasma soluble HLA-G levels are associated with active Zika- and Chikungunya-virus infection in Brazilian patients exhibiting neurological manifestations"

Maria Lucia Brito Ferreira, Renata dos Santos Almeida, Paulin Sonon, Ibrahim Sadissou, Tom Solomon, Eduardo Antônio Donadi, Norma Lucena-Silva

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"HLA-G in Immunospychiatry: The Contribution to Bipolar Disorder"

Ching-Lien Wu, Aparna Sundaresh, Monojit Debnath, Christina Mary Mariaselvam, Wahid Boukouaci, Céline Manier, Rajagopal Krishnamoorthy, Joel LeMaoult, Vir Singh Negi, Marion Leboyer, Ryad Tamouza

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"Analysis of the HLA-G*14bp insertion/deletion polymorphism in Autism Spectrum Disorder patients"

Marina Ziliotto, Valéria de Lima Kaminski, Jaqueline Bohrer Schuch, Rudimar dos Santos Riesgo, Lavinia Schuler-Faccini, Tatiana Roman, José Artur Bogo Chies.

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"HLA-G 14 bp Ins/Del polymorphism and +3142 C/G SNP are not related to Neuromyelitis Optica Spectrum Disorder (NMOSD) development, disability status or anti-Aquaporin 4 presence in Brazilian patients"

Nathália Augusta Gomes, Pollyanna Silva, Ygor Teixeira, Patrícia Eufrazio, Alessandra Souza, Hugo Rojas, Renata Brant, Antônio Gomes Neto, Paulo Pereira Christo, Renata Toscano Simões, Karla Silva Fernandes

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"HLA-G 3’UTR haplotype analyses in HCV infection and HCV-derived cirrhosis and hepatocellular carcinoma"

Julio Daimar Oliveira Correa, Francis Maria Báo Zambra, Rafael Tomoya Michita, Valéria Lima Kaminski, Daniel Simon, José Artur Bogo Chies

_________________________________________________________________________________________________________________  "HLA-G expression in leprosy"

Camila Rodrigues da Silva, Lucas Henrique Ferreira Sampaio, Maurício Barcelos Costa, Ibrahim Abiodoun Sadissou, Mírian Lane de Oliveira Rodrigues Castilho, Renata Toscano Simões, Eduardo Antonio Donadi, Isabela Jubé Wastowski

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"The Human leukocyte antigen-G (HLA-G) molecule is associated with Whipple’s disease and Tropheryma whipplei infections"

Eya Ben Azzouz, Christophe Picard, Asma Boumaza, Soraya Mezouar, Matthieu Bardou, Federico Carlini, Didier Raoult, Jean-Louis Mège, Benoit Desnues

_________________________________________________________________________________________________________________   "Redirection of immune cells specificity against HLA-G: anti-HLA-G CAR T cells"

François Anna, Maria Loustau, Simon Wain-Hobson, Pierre Langlade-Demoyen, Caumartin Julien

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  JULY 9, 2019


PLENARY SESSION 
3

 HLA-G IN CANCER


Chairpersons : Barbara Seliger, François Desgrandchamps

09:00 - 10:20 

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Joël LeMaoult : "CD8+PD1negILT2+ T cells, a major intratumor cytotoxic population inhibited by HLA-G"

France

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Wei-Hua Yan : "Heterogeneity and clinical significance of HLA-G in cancers"

Chine

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Vera Rebmann : "Systematic evaluation of the clinical importance of HLA-G in breast  cancer"

Germany

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Christophe Hennequin : "Interactions of radiotherapy and the immune system"

France

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COFFEE BREAK 10:20 - 10:40

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PLENARY SESSION 4

HLA-G REGULATION AND EXPRESSION


Chairpersons : Diana Le Roux, Ofer Mandelboim

10:40 - 12:00 

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Philippe Moreau : "An update on the regulation of HLA-G expression. 

France

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Barbara Seliger : "Post-transcriptional control of HLA-G and its role on the tumor phenotype"

Germany   

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Soldano Ferrone  : "Epigenetic mechanisms and HLA defects in malignant cells"

USA

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Eduardo A. Donadi : "Diversity of the HLA-G gene: implication on function"

Brazil

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SYMPOSIUM

III

HLA-G IN ALLOGRAFT AND MSC

Chairpersons: Olivier BRUGIERE, Diego DELGADO

 

12:00 - 13:15

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"HLA-G dimer inhibits activation of CD8+ T cells and Granzyme B expression to prolong human kidney allograft survival" sss

Ashwin Ajith, Vera Portik-Dobos, Anh Thu Nguyen-Lefebvre, Christine Callaway,Daniel David Horuzsko, Rajan Kapoor, Carlos Zayas, Katsumi Maenaka, Laura L. Mulloy, Anatolij Horuzsko ssssssssssssssssssssssssssssssssssssssssssssssssss  sssssss

_________________________________________________________________________________________________________________Dynamic "Dynamic expression of HLA-G during Kidney Transplant"

Silvia Marçal Botelho, Isabela Jubé, Renata Toscano Simões, Nilzio Antônio da Silva.

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"HLA-G 14BP Polymorphism Donor/Recipient Matching Protects Against Development of Post-Transplant Malignancy Following Heart Transplantation"

Mitchell B. Adamson, Roberto V.P. Ribeiro, Frank Yu, Julieta Lazarte, Kyle Runeckles, Cedric Manlhiot,  Vivek Rao, Diego Delgado

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"Proinflammatory cytokine and hypoxic condition stimuli enhances the immunomodulatory property of tissue specific mesenchymal stem cells"

Mohanty Sujata, Rawat Sonali, Gupta Suchi

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"Priming of tissue specific human mesenchymal stem cells with glucocorticoid: implication in immunomodulation"

Rawat Sonali, Das Jyoti, Mann Zoya, Mohanty Sujata

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"Comparative analysis of HLA-G expression by mesenchymal stem cells from different sources"

Bernardo Zoehler, Letícia Fracaro, José Samuel da Silva, Alexandra Cristina Senegaglia, Maria da Graça Bicalho

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"Identification of immunomodulatory capacities of mesenchymal stem cells derived from Wharton’s jelly during cell differentiation"

Charlotte Voisin, Valentine Wang, Ghislaine Cauchois, Loïc Reppel, Caroline Laroye, Hélène Antonot,   Nadia Benkirane-Jessel, Philippe Moreau, Nathalie Rouas-Freiss, Edgardo D. Carosella, Danièle Bensoussan, Céline Huselstein

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"Cells differentiated from mesenchymal stem cells for the treatment of dermal lesions"

Marcela García, Guillermo Buero, Maria Belen Palma, Santiago Miriuka, Laura B. Andrini, Ana M Inda,      Ana L Errecalde, Edgardo D. Carosella

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LUNCH BREAK 13:15 - 14:15

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PLENARY SESSION

5

HLA-G IN PREGNANCY


Chairpersons : Silvia Gregori, Philippe Moreau 

14:15 - 15:35 

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Paola Vigano : "Exploiting the value of preimplantation embryo-derived HLA-G in aiding IVF care"

Italy                  

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Tamara Tilburgs : "The role of HLA-G+ trophoblasts in maternal-fetal immune tolerance"

USA

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Thomas V. Hviid : "HLA class Ib in reproduction and pregnancy complications"

Denmark

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Daria Bortolotti  :"HLA-G implication in viral infections during pregnancy"

Italy

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COFFEE BREAK 15:35 - 16:00

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SYMPOSIUM

IV

 

HLA-G IN PREGNANCY

Chairpersons : Thomas V. HVIID, Francesco PUPPO

 

16:00 - 17:15

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 "Impact of the cytokine environment on the expression of the tolerogenic HLA-G molecule in pregnancy and pre-eclampsia"

Gry Persson, Julie B.S. Bork, Cecilie Isgaard, Tine G. Larsen, Thomas Vauvert Faurschou Hviid 

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"Immunohistochemical determinants of HLA-G expression in early reproductive losses"

Margarita Bakleicheva, Olesya Bespalova, Irina Kovaleva, Tatiana Ivashchenko, Gulrukhsor Tolibova, Tatiana Tral

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"Correlation of the soluble HLA-G plasma level and its genetic polymorphism with pregnancy outcome of patients undergoing in vitro fertilization embryo transfer"

Karolina Wilczyńska, Andrzej Wiśniewski, Rafał Krasiński, Paweł Radwan, Michał Radwan, Jacek R. Wilczyński, Andrzej Malinowski, Piotr Kuśnierczyk, Izabela Nowak

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"The role of ERAP1, ERAP2 and HLA-G polymorphism in secretion profile of HLA-G in patients undergoing in vitro fertilization embryo transfer"

Karolina Wilczyńska, Andrzej Wiśniewski, Rafał Krasiński, Paweł Radwan, 3, Michał Radwan, Jacek R. Wilczyński, Andrzej Malinowski, Piotr Kuśnierczyk, Izabela Nowak.

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"Transcriptional regulation of HLA-G at the maternal-fetal interface"

Leonardo M. R. Ferreira, Torsten B. Meissnera, Hannah A. B. Gomesa, Andrew Mazzantia, Tamara Tilburgs, Chad A. Cowana, Jack L. Strominger

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"Targeted Monoclonal anti-α3 domain of HLA-G"

Julien Caumartin, Pierre Langlade-Demoyen, Simon Wain-Hobson, Maria Loustau

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"Hookworm infections and levels of soluble HLA-G in Beninese pregnancy women"

Euripide Avokpaho, Tania C. d’Almeida, Ibrahim Sadissou, Léonidas Tokplonou,, Rafiou Adamou, Paulin Sonon, Jacqueline Milet, Gilles Cottrell, Amandine Mondière, Achille Massougbodji, Kabirou Moutairou, Eduardo A. Donadi, Benoit Favier, Edgardo Carosella, Philippe Moreau, Nathalie Rouas-Freiss, André Garcia, David Courtin.

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"Association of IL-17/RIL-17 and immunoregulatory gene polymorphism in pregnancy with co-infection HPV/HIV on antiretroviral terapy"        

Rayanne S. P. Morais, Marcos G. Santos, Paulin Sonon, Daniel A. V. Pascoal, Ricardo N. O. Cobucci, Kleyton T. C. Carvalho, Norma L. Silva, Eduardo A. Donadi, Janaína C. O. Crispim

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COCKTAIL 18:45

Fondation Dosne-Thiers

27 place Saint-Georges, 75009 Paris


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JULY 10, 2019

PLENARY SESSION 6

HLA-G IN TRANSPLANTATION


Chairpersons: Nathalie Rouas-Freiss, Anatolij Horuzsko

09:00 - 11:00 

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Diego Delgado : "Role of HLA-G in cardiac transplantation and beyond"

Canada

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Olivier Brugière : "Peripheral immunosuppressive cells in lung transplantation: Focus on the inhibitory checkpoint HLA-G"

France

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Hana Rohn: "HLA-G and HLA-E in solid organ transplantation"

Germany

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Danièle Bensoussan: "Mesenchymal stem cells as immunomodulatory therapeutic agents:  from bench to bedside"

France

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Hisashi Arase: "LILR family receptors in host-pathogen interaction"

Japan

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David Courtin: "Human leukocyte antigen-g and predisposition to malaria and human African trypanosomiasis"

France                                                              


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COFFEE BREAK 11:00 - 11:20

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PLENARY SESSION 7

HLA-G AND NEUROLOGICAL DISORDERS

Chairpersons : Roberta Rizzo, Edgardo D. Carosella

11:20 - 13:00

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Fabio Malavasi, Tribute to Professor Baricordi 

Italy

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Francesco Puppo : "Membrane and soluble HLA-G in systemic sclerosis"

Italy

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Enrico Fainardi  : "Neurological implication of HLA-G"

Italy

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Antonio A. Villena : "HLA-G polymorphism  worldwide : significance in epidemiology and evolution"

Spain

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16:00   Closing remarks 

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LUNCH BREA13:00 - 14:00

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